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. 2017 Oct;27(10):1665–1673. doi: 10.1101/gr.222505.117

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© 2017 Liufu et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 6. — Phenotypic rescue by restoring the expression of individual target genes. The red dotted line, indicating the phenotypic value of mir310s- flies, demarcates positive and negative rescue. The black line indicates the wild-type value, hence denoting full rescue. (A) Dorsal appendages: Four genes with their expression restored by RNAi rescue the phenotypic defect. More than 200 eggs were examined for each genotype. (B) Egg hatchability: Only one gene (Mad) shows full rescue, and a second one (Dl) shows partial but insignificant rescue. The remaining three genes (E2f2, EcR, and Mef2) show negative rescue. (C) Male fertility (progeny count for males in the first round of mating). Only one gene (Mad) shows full rescue. The rest show negative rescue, which is statistically significant for three genes (E2f2, EcR, and Mef2) and insignificant for one (Dl). More than 15 individual males were tested for each genotype. (*) P < 0.05, (**) P < 0.01, (***) P < 0.001 by Student's t-test.