. 2017 Sep 27;11:1677–1686. doi: 10.2147/PPA.S139851

Table 3.

Barriers to prophylaxis adherence and potential strategies for addressing these barriers

Barriers to adherence²⁸,³¹,⁴²,⁴⁵–⁴⁹	Potential strategies to improve adherence⁵⁰–⁵⁶
• Patient-related factors ◦ Health beliefs ◦ Age • Condition-related factors ◦ Frequency of bleeding • Treatment-related factors ◦ Venous access ◦ Dosing regimen ◦ Cost ◦ Perceived costs • Health-care system factors ◦ Access to hemophilia-treatment center ◦ Insurance • Socioeconomic factors ◦ Language ◦ Acculturation ◦ Health literacy ◦ Balancing the child’s care with other family and social needs	• Education (multimedia, peer-to-peer mentors, tailored to patient’s primary language, development, and health literacy) ◦ Benefits of prophylaxis ◦ Venous access ◦ Health-care navigation ◦ Patient portals in ehealth records • Monitoring ◦ Logs ◦ Mobile direct observation • Reminders ◦ Text messaging ◦ Phone app • Incentives (age-appropriate) ◦ Reward charts ◦ Financial

Barriers to adherence²⁸,³¹,⁴²,⁴⁵–⁴⁹

Potential strategies to improve adherence⁵⁰–⁵⁶

• Patient-related factors
◦ Health beliefs
◦ Age
• Condition-related factors
◦ Frequency of bleeding
• Treatment-related factors
◦ Venous access
◦ Dosing regimen
◦ Cost
◦ Perceived costs
• Health-care system factors
◦ Access to hemophilia-treatment center
◦ Insurance
• Socioeconomic factors
◦ Language
◦ Acculturation
◦ Health literacy
◦ Balancing the child’s care with other family and social needs

• Education (multimedia, peer-to-peer mentors, tailored to patient’s primary language, development, and health literacy)
◦ Benefits of prophylaxis
◦ Venous access
◦ Health-care navigation
◦ Patient portals in ehealth records
• Monitoring
◦ Logs
◦ Mobile direct observation
• Reminders
◦ Text messaging
◦ Phone app
• Incentives (age-appropriate)
◦ Reward charts
◦ Financial