Table 6.
Classification of antiepileptic agents detected in the toxicological analysis
| Treatment | All cases | Deaths caused by epilepsy | Deaths caused by cardiovascular disease | p | |||
|---|---|---|---|---|---|---|---|
| n | % | n | % | n | % | ||
| None | 61 | 58.1 | 21 | 55.3 | 11 | 78.6 | 0.437 * |
| Monotherapy | 35 | 33.3 | 12 | 31.6 | 2 | 14.3 | |
| Polytherapy | 9 | 8.6 | 5 | 13.2 | 1 | 7.1 | |
| Total (Patients with postmortem toxicological screening) | 105 | 100 | 38 | 100 | 14 | 100 | |
| Monotype antiepileptics | |||||||
| Agents with ureit structure | 15 | 42.9 | 2 | 16.7 | 2 | 100 | |
| Barbiturate analogs | 4 | 11.4 | 1 | 8.3 | - | - | |
| Hydantoins | 5 | 14.3 | 1 | 8.3 | 1 | 50 | |
| Barbiturates and Hydantoins | 6 | 17.1 | - | - | 1 | 50 | |
| Dibenzazepine analogs | 11 | 31.4 | 5 | 41.7 | - | - | |
| Valproic acid analogs | 5 | 14.3 | 2 | 16.7 | - | - | |
| New generation | 3 | 8.6 | 3 | 25.7 | - | - | |
| Benzodiazepines | 1 | 2.9 | - | - | - | - | |
| Total | 35 | 100 | 12 | 100 | 2 | 100 | |
| Combination of antiepileptics | |||||||
| Ureit-type drugs+Benzodiazepines | 3 | 33.33 | 2 | 40 | - | - | |
| Ureit-type drugs+Dibenzazepine analogues | 2 | 22.22 | 1 | 20 | - | - | |
| Ureit-type drugs+Valproic acid analogues | 2 | 22.22 | 1 | 20 | - | - | |
| Ureit-type drugs+New generation | 1 | 11.11 | 1 | 20 | - | - | |
| Dibenzazepine analogs+Valproic acid analogs+New generation | 1 | 11.11 | - | - | 1 | 100 | |
| Total | 9 | 100 | 5 | 100 | 1 | 100 | |
*
Fisher–Freeman–Halton Test