Table 2. Results for primary and secondary outcomes at 2 years using linear mixed-models.
| Change | Care coordinator |
Treatment as usual |
P (group x time) |
|
|---|---|---|---|---|
| Primary outcome | ||||
| 10-year risk of cardiovascular disease (%) | ||||
| Mean±SDa | 8.7±6.0 | 7.7±5.7 | 8.0±6.3 | 0.235 |
| Secondary outcomes | ||||
| Weight (Kg) | ||||
| Mean±SDa | 105.9±22.2 | 103.7±22.1 | 104.9±22.1 | 0.177 |
| Body mass index | ||||
| Mean±SDa | 35.6±8.6 | 34.4±8.7 | 34.4±8.6 | 0.131 |
| Waist circumference (cm) | ||||
| Mean±SDa | 114.8±17.0 | 114.9±17.1 | 117.0±16.8 | 0.834 |
| Systolic blood pressure (mm Hg) | ||||
| Mean±SDa | 129.1±13.0 | 130.1±13.5 | 128.3±13.4 | 0.522 |
| Resting heart rate (beats/min) | ||||
| Mean±SDa | 82.3±13.7 | 85.1±13.8 | 85.5±13.7 | 0.534 |
| Cardiorespiratory fitness (ml O2/min/Kg) | ||||
| Mean±SDa | 17.7±5.8 | 19.0±5.8 | 17.5±5.8 | 0.717 |
| Forced expiratory volume (L/min) | ||||
| Mean±SDa | 3.1±0.6 | 3.2±0.6 | 3.1±0.6 | 0.614 |
| HbA1c (mmol/mol) | ||||
| Mean±SDa | 39.7±7.8 | 39.3±8.1 | 39.3±8.0 | 0.731 |
| Total cholesterol (mmol/l) | ||||
| Mean±SDa | 5.02±1.0 | 4.94±1.0 | 5.04±1.1 | 0.693 |
| HDL cholesterol (mmol/l) | ||||
| Mean±SDa | 1.12±0.3 | 1.2±0.4 | 1.28±0.3 | 0.447 |
| Triglycerides (mmol/l) | ||||
| Mean±SDa | 2.1±1.7 | 2.1±1.8 | 2.3±1.8 | 0.665 |
| Hs-CRP (mg/l) | ||||
| Mean±SDa | 5.3±5.3 | 5.0±5.4 | 4.7±5.4 | 0.446 |
| Moderate-vigorous physical activity (hours/week) | ||||
| Mean±SDa | 2.6±5.9 | 2.9±5.9 | 2.8±6.0 | 0.811 |
| Time spent Sedentary (hours/day) | ||||
| Mean±SDa | 10.4±3.7 | 10.3±3.7 | 10.3±3.6 | 0.839 |
| Daily smoking (yes/no) | ||||
| % (chi-square statistics)b | 50.7 (0.03) | 47.6 (0.01) | 49.3 (0.01) | 0.963 |
| Intake of fruit (g/week) | ||||
| Mean±SDa | 346.6±201.0 | 331.1±229.1 | 334.6±216. | 0.392 |
| Intake of vegetables (g/week) | ||||
| Mean±SDa | 542.1±294.8 | 455.6±295.1 | 486.6±294.7 | 0.061 |
| Intake of fish (g/week) | ||||
| Mean±SDa | 119.0±113.9 | 137.0±114.0 | 139.7±113.7 | 0.746 |
| Positive symptoms (SAPS global score) | ||||
| Mean±SDa | 1.6±1.1 | 1.5±1.3 | 1.4±1.2 | 0.174 |
| Negative symptoms (SANS global score) | ||||
| Mean±SDa | 1.7±1.0 | 1.5±1.0 | 1.5±1.1 | 0.781 |
| Cognition (BACS composite score) | ||||
| Mean±SDa | 254.3±44.9 | 251.2±45.6 | 251.6±46.5 | 0.445 |
| Quality of life (MANSA score) | ||||
| Mean±SDa | 4.8±0.1 | 4.9±0.1 | 4.9±0.1 | 0.60 |
| GAF total score | ||||
| Mean±SDa | 48.6±10.8 | 48.1±10.7 | 48.1±10.78 | 0.792 |
| Perceived health | ||||
| Mean±SDa | 3.4±0.9 | 3.4±0.9 | 3.4±0.9 | 0.849 |
Hs-CRP—high sensitivity C-reactive protein, SAPS—Scale for the Assessment of Positive Symptoms, SANS—Scale for the Assessment of Negative Symptoms, BACS—Brief Assessment of Cognition in Schizophrenia, MANSA—Manchester Short Assessment of Quality of Life, GAF—Global Assessment of Functioning, HDL—high density lipoprotein· HbA1c—hemoglobin A1c
a after mixed model analysis, adjusted for sex, research center and baseline risk of cardiovascular disease
b after imputation with predictors: sex, age, randomization, smoking status at baseline and 1 year follow-up. 100 imputations, 20 iterations