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. 2017 Sep 26;13(9):e1007034. doi: 10.1371/journal.pgen.1007034

Fig 6. The GLP mutation rescues abnormal sex differentiation of XY Jmjd1a-deficient embryos.

Fig 6

(A) Evaluation of sex differentiation of E13.5 embryonic gonads by immunofluorescence analysis. Sox9 and Foxl2 mark testicular Sertoli and ovarian somatic cells, respectively. The enlarged box indicates that the GLP mutation rescued the tubule-like structure that was absent in XY Jmjd1aΔ/Δ gonads. Scale bar, 200 μm. (B) Quantification of Sox9- and Foxl2-positive cells in E13.5 gonads of the indicated genitypes. Numbers of embryos examined are shown above the bars. Data are presented as mean ± SD. * P < 0.05; ** P < 0.01.