Table 2.
Top 20 AD Genes, as Predicted by DOMINO
| Gene | P(AD) | In training set | Main OMIM description |
|---|---|---|---|
| SF3B1 [MIM:605590] | 0.999999 | No | Myelodysplastic syndrome, somatic/dominant [MIM:614286] |
| CSNK2A1 [MIM:115440] | 0.999998 | No | Okur-Chung syndrome, autosomal dominant [MIM:617062] |
| LHX2 [MIM:603759] | 0.999998 | No | Unassigned |
| DACH1 [MIM:603803] | 0.999998 | No | Unassigned |
| PAX6 [MIM:607108] | 0.999998 | Yes, AD | Aniridia, autosomal dominant [MIM:106210] |
| PRPF8 [MIM:607300] | 0.999996 | No | Retinitis pigmentosa, autosomal dominant [MIM:600059] |
| ATP2B1 [MIM:108731] | 0.999996 | No | Unassigned |
| DYNC1H1 [MIM:600112] | 0.999996 | Yes, AD | Charcot-Marie-Tooth disease, axonal, autosomal dominant [MIM:614228] |
| PIK3CA [MIM:171834] | 0.999995 | Yes, AD | Cowden syndrome 5, autosomal dominant [MIM:615108] |
| PTEN [MIM:601728] | 0.999995 | No | Bannayan-Riley-Ruvalcaba syndrome, autosomal dominant [MIM:153480] |
| TBL1XR1 [MIM:608628] | 0.999995 | No | Intellectual disability, autosomal dominant [MIM:616944] |
| HNRNPR [MIM:607201] | 0.999994 | No | Unassigned |
| TOP2B [MIM:126431] | 0.999994 | No | Unassigned |
| GSK3B [MIM:605004] | 0.999993 | No | Unassigned |
| CDK8 [MIM:603184] | 0.999992 | No | Unassigned |
| XPO1 [MIM:602559] | 0.999992 | No | Unassigned |
| SREBF1 [MIM:184756] | 0.999992 | No | Unassigned |
| PIAS1 [MIM:603566] | 0.999991 | No | Unassigned |
| NR2F2 [MIM:107773] | 0.999991 | Yes, AD | Congenital heart defects, autosomal dominant [MIM:615779] |
| BCL11B [MIM:606558] | 0.999990 | No | Immunodeficiency 49, autosomal dominant [MIM:617237] |