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. 2017 Sep 27;6:e31362. doi: 10.7554/eLife.31362

Figure 6. Gata6-driven SMC differentiation promotes survival of the posterior AAs.

Figure 6.

Gata6 activates Myocd and Jag1 to initiate SMC differentiation in the cardiac NC, migrating to BA3-6. Generation of SMCs in BA3-6, and their recruitment by AA3-6, results in the stabilization of these vessels and their subsequent incorporation into the mature aortic tree. Conversely, because Gata6 is not expressed in BA1-2, AA1-2 do not ‘see’ any SMC and eventually regress. Auto-regulatory loops involving GATA TFs are likely features of Gata6 network. Arrows and double arrow indicate regulation and interaction, respectively; broken arrows indicate links that are not experimentally validated.