Table 4. Multivariate analysis of marital status on liver cancer overall and cause-specific survival according to different SEER stage.

Characteristic	OS HR (95% CI)	P	CSS HR (95% CI)	P
Localized
Married	Reference		Reference
Divorced/Separated	1.11 (1.05–1.17)	< 0.001	1.10 (1.03–1.16)	0.005
Widowed	1.41 (1.33–1.51)	< 0.001	1.36 (1.27–1.46)	< 0.001
Single	1.28 (1.22–1.34)	< 0.001	1.22 (1.16–1.29)	< 0.001
Regional
Married	Reference		Reference
Divorced/Separated	1.07 (1.01–1.14)	0.022	1.06 (0.99–1.13)	0.091
Widowed	1.19 (1.11–1.29)	< 0.001	1.16 (1.08–1.26)	0.001
Single	1.11 (1.06–1.17)	< 0.001	1.09 (1.03–1.15)	0.002
Distant
Married	Reference		Reference
Divorced/Separated	1.14 (1.06–1.23)	< 0.001	1.14 (1.06–1.24)	0.001
Widowed	1.14 (1.04–1.24)	0.004	1.12 (1.02–1.22)	0.016
Single	1.10 (1.04–1.18)	0.002	1.07 (1.01–1.15)	0.034

Abbreviations

OS, Overall survival; CSS, Cause-specific survival; HR, Hazard ratio; SEER, Surveillance, Epidemiology, and End Results.

Adjusted covariates for gender, age, race, grade, histotype, and therapy.