Figure 4. The down-regulation of SOX7 expression in BCP-ALL cells induces a significant decrease in clonogenicity.
A-B. RS4;11 and NALM6 human leukemia cells transduced with the indicated shRNA were cultured in semi-solid clonogenic assays. Data represent colony number after 10 days in culture (n=3, * P<0.05; ** P<0.01). C-D. Representative pictures of colonies obtained from RS4;11 and NALM6 replating in colony assay at day 10. Scale bars represent 100μm (Leica scan and software). Data are representative of three independent experiments.