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. 2017 May 10;8(39):65077–65089. doi: 10.18632/oncotarget.17779

Figure 1. SC-43 exerts anti-proliferative and apoptosis-inducing effects in cholangiocarcinoma (CCA) cells.

Figure 1

SC-43, a derivative of sorafenib induces apoptosis in CCA cell lines. (A) immunohistochemical (IHC) staining for p-STAT3 in CCA tumor (left), compared with normal tissue part (right). (B) dose-escalation effects of SC-43 on cell viability. Cells were exposed to SC-43 at the indicated doses for 24, 48, and 72 hours respectively and cell viability was assessed by MTT assay. Points, mean; bars, SD (n = 9). (C) effects of SC-43 on apoptosis. Cells were exposed to SC-43 at the indicated doses for 24 hours and number of apoptotic cells was determined by flow cytometry. Columns, mean; bars, SD (n = 3). (D) SC-43-induced apoptosis-related signals in cells.