Skip to main content
. 2017 May 10;8(39):65077–65089. doi: 10.18632/oncotarget.17779

Figure 4. SC-43 activates SHP-1 by relieving the autoinhibition of the SH2 domain.

Figure 4

(A) schematic representation of deletion and single mutants of SHP-1. (B) dN1 and D61A impair SC-43-induced STAT3 signaling and apoptotic effect. Apoptotic assay was performed by sub-G1 analysis. Columns, mean; bars, SD (n = 3). **P < 0.01. (C) dose-dependent dN1 and D61A plasmid transfection suppressed p-STAT3 expression and decreased SC-43-induced p-STAT3 downregulation.