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. 2017 May 19;8(39):65171–65185. doi: 10.18632/oncotarget.18015

Table 3. Univariate and multivariate analysis in the whole population.

Variable Median survival (months) Univariate analysis Multivariate analysis
HR 95% CI P value HR 95% CI P value
Sex 0.613 0.428-0.878 0.008** 0.565 0.391-0.816 0.002**
 Male 16
 Female 24
Age 1.027 0.781-1.35 0.849
 ≥70 18
 <70 19
Tumor location 1.109 0.942-1.305 0.215
 Upper 21
 Middle 14
 Lower 17
T stage 1.908 1.552-2.345 <0.001*** 1.298 1.056-1.596 0.013**
 T1-2 22
 T3 15
 T4 7
N stage 2.483 2.041-3.021 <0.001*** 2.311 1.877-2.846 <0.001***
 N1 41
 N2 20
 N3 9
TNM stage 2.939 2.082-4.149 <0.001*** 2.307 1.541-3.456 <0.001***
 II 43
 III 19
 IV 8
Supraclavicular nodes 1.038 0.792-1.359 0.789
 Positive 19
 Negative 17
Left gastric nodes 0.762 0.572-1.015 0.063
 Positive 14
 Negative 21
Celiac nodes 0.416 0.304-0.567 <0.001*** 0.599 0.416-0.862 0.006**
 Positive 11
 Negative 22
Common hepatic nodes 0.291 0.194-0.435 <0.001*** 0.417 0.260-0.669 <0.001***
 Positive 7
 Negative 21
Treatment modality 1.588 1.184-2.13 0.002** 1.754 1.304-2.359 <0.001***
 Chemoradiotherapy 21
 Radiotherapy alone 11
Radiation dose 1.630 1.245-2.134 <0.001*** 1.388 1.058-1.820 0.018*
 ≥60 Gy 22
 <60 Gy 13

*, P < 0.05; **, P < 0.01; ***, P < 0.001.