Table 4. Univariate and multivariate analysis in patients with upper ESCC.
| Variable | Median survival (months) | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | ||
| Sex | 0.560 | 0.311-1.009 | 0.053 | ||||
| Male | 20 | ||||||
| Female | 26 | ||||||
| Age | 0.921 | 0.568-1.492 | 0.737 | ||||
| ≥70 | 24 | ||||||
| <70 | 20 | ||||||
| T stage | 2.169 | 1.544-3.046 | <0.001*** | 1.553 | 1.090-2.212 | 0.015* | |
| T1-2 | 43 | ||||||
| T3 | 24 | ||||||
| T4 | 17 | ||||||
| N stage | 2.256 | 1.617-3.149 | <0.001*** | 1.811 | 1.221-2.686 | 0.003** | |
| N1 | 43 | ||||||
| N2 | 20 | ||||||
| N3 | 11 | ||||||
| TNM stage | 3.417 | 2.002-5.832 | <0.001*** | 2.157 | 1.148-4.054 | 0.017* | |
| II | 43 | ||||||
| III | 22 | ||||||
| IV | 8 | ||||||
| Supraclavicular nodes | 0.898 | 0.534-1.510 | 0.685 | ||||
| Positive | 22 | ||||||
| Negative | 20 | ||||||
| Left gastric nodes | 0.680 | 0.370-1.247 | 0.213 | ||||
| Positive | 17 | ||||||
| Negative | 22 | ||||||
| Celiac nodes | 0.413 | 0.235-0.724 | 0.002** | 0.457 | 0.256-0.816 | 0.008** | |
| Positive | 13 | ||||||
| Negative | 25 | ||||||
| Common hepatic nodes | 0.144 | 0.058-0.354 | <0.001*** | 0.241 | 0.092-0.630 | 0.004** | |
| Positive | 3 | ||||||
| Negative | 22 | ||||||
| Treatment modality | 1.499 | 0.880-2.553 | 0.136 | ||||
| Chemoradiotherapy | 22 | ||||||
| Radiotherapy alone | 10 | ||||||
| Radiation dose | 1.940 | 1.193-3.153 | 0.008** | 1.355 | 0.786-2.337 | 0.274 | |
| ≥60 Gy | 26 | ||||||
| <60 Gy | 12 | ||||||
ESCC, esophageal squamous cell carcinoma; *, P < 0.05; **, P < 0.01; ***, P < 0.001.