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. 2017 May 25;8(39):65230–65239. doi: 10.18632/oncotarget.18191

Figure 4. A20-dependent TAK1 activity reduced eNOS expression through regulating p38 MAPK in HUVECs.

Figure 4

(A) TNFα-caused phosphorylation p38 (p-p38) MAPK expression (B) The effect of A20 on TNFα-induced p38 MAPK protein levels pretreated with AdsiA20, AdsiTAK1 or AdA20, respectively. (C) P38 expressions were examined in HUVECs pre-treated with Adsip38 siRNA (it’s scramble siRNA as negative control) (D) The effect of Adsip38 MAPK on TNFα-induced p-eNOS expression in HUVECs. (E) Relative quantification of NO release in TNFα -treated HUVECs with or without pre-treatment of Adsip38 MAPK. (F) TAK1-mediated impact on eNOS occurs through the expression of p38 MAPK. Data represented typical results of 4 independent experiments.