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. 2017 Jul 3;8(39):65457–65468. doi: 10.18632/oncotarget.18924

Figure 1. Effects of miR-200c on radiation response and EGFR-associated signaling.

Figure 1

Ectopic overexpression of miR-200c inhibited expression of p-EGFR and downstream signaling molecules PI3K 110а, p-AKT, and p-ERK, and increased the radiosensitivity of U251 (A), T98G (B), A549 (C), and MDA-MB-468 (D) cells. In contrast, miR-200c inhibition upregulated the expression of the above proteins and decreased radiation-induced cell killing. Points on the survival curves represent surviving fractions calculated from cells treated in triplicate. Each experiment was also repeated three times with similar results.