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. 2017 Aug 9;8(39):65699–65716. doi: 10.18632/oncotarget.20081

Figure 4. Distinct epigenetic regulator profiles according to the 3 cytosine derivative subgroups.

Figure 4

Epigenetic regulators are tested by real time PCR and expressed relative to GAPDH: the DNA methylation ‘writers’, DNMT1/3A; ‘readers’, MBD2/4; ‘editors’, TET1/2/3; and the ‘modulator’ SAT1. (A) Fold changes of epigenetic regulators between the chronic lymphocytic leukemia (CLL) global subgroup (n = 9) compared to the CLL normal subgroup (n = 13). (B) Fold changes of epigenetic regulators between the CLL Partial subgroup (n = 11) compared to the CLL Normal subgroup. Statistical differences between Global and Partial subgroups versus Normal subgroup were assessed using the non-parametric Mann-Whitney test and P < 0.05 are indicated as follows: (***) P < 0.001; (**) 0.001 < P < 0.01; (*) 0.01 < P < 0.05.