Figure 6. Biodistribution of ⁸⁹Zr-DFO-MPA1 in selected tissues of mice xenografts.

(A) Biodistribution in mice bearing bilateral K562 xenografts, examined at multiple time points (n = 4-5 per group) showing peak tumor uptake at 24 hours. (B) Significantly (p<0.01) lower uptake of ⁸⁹Zr-DFO-MPA1 was noted in PRAME negative xenograft BLCL (n = 4) at 72 hours. (C) Biodistribution in mice bearing bilateral THP-1 xenografts. Tissue uptake revealed a similar pattern, with peak tumor uptake at 48 hours. A separate blocking group (n=4) at 24 hours were co-administered tracer with unlabeled MPA1 that significantly (p<0.01) decreased tumor uptake. Data is expressed as mean %IA/g (± one standard deviation). (D/E) Biodistribution in mice bearing bilateral LNCaP-AR s.c. xenografts, a PRAME positive solid tumor, showed significantly (P < 0.01) higher ⁸⁹Zr-DFO-MPA1 tumor uptake than BT474 s.c. xenografts, a PRAME negative solid tumor.