Table 2.
Full ex vivo biodistribution data of 89Zr-DFO-MPA1 over time (hours, h) in PRAME negative BT474 (A) and positive LNCaP-AR (B) tumor bearing male BALB/c mice
| A. BT474 | |||
|---|---|---|---|
| 4 h | 24 h | 72 h | |
| Blood | 22.2 ± 1.9 | 13.6 ± 2.0 | 7.6 ± 3.4 |
| Tumor | 5.4 ± 2.6 | 2.8 ± 1.3 | 1.7 ± 0.5 |
| Heart | 10.1 ± 2.3 | 5.5 ± 0.8 | 1.9 ± 1.5 |
| Lungs | 13.1 ± 5.3 | 7.9 ± 1.6 | 3.3 ± 3.6 |
| Liver | 15.9 ± 1.4 | 9.7 ± 0.7 | 9.8 ± 10.4 |
| Spleen | 7.4 ± 6.1 | 5.3 ± 0.9 | 1.9 ± 1.6 |
| Stomach | 1.5 ± 1.2 | 1.4 ± 0.1 | 0.6 ± 0.4 |
| Sm. Intestine | 2.9 ± 0.6 | 2.2 ± 0.4 | 0.7 ± 0.4 |
| Lg. Intestine | 4.5 ± 2.1 | 1.8 ± 0.2 | 2.1 ± 1.9 |
| Kidneys | 6.9 ± 3.6 | 5.5 ± 0.5 | 3.9 ± 3.0 |
| Muscle | 1.3 ± 0.3 | 1.6 ± 0.4 | 0.8 ± 0.6 |
| Bone | 2.5 ± 0.9 | 1.5 ± 0.2 | 0.8 ± 0.6 |
| Tail | 4.2 ± 0.6 | 4.7 ± 3.6 | 1.2 ± 0.2 |
| B. LNCaP-AR | |||
|---|---|---|---|
| 4 h | 24 h | 72 h | |
| Blood | 26.8 ± 7.6 | 17.6 ± 3.1 | 13.9 ± 3.3 |
| Tumor | 3.7 ± 1.1 | 6.4 ± 0.8 | 5.9 ± 0.6 |
| Heart | 8.5 ± 0.4 | 6.3 ± 1.6 | 3.1 ± 1.0 |
| Lungs | 11.1 ± 2.4 | 8.8 ± 1.8 | 5.1 ± 1.3 |
| Liver | 14.7 ± 2.6 | 10.7 ± 3.1 | 9.2 ± 1.0 |
| Spleen | 14.1 ± 1.5 | 10.0 ± 2.4 | 7.4 ± 1.5 |
| Stomach | 1.1 ± 0.4 | 1.2 ± 0.2 | 0.8 ± 0.4 |
| Sm. Intestine | 2.7 ± 0.5 | 2.7 ± 0.5 | 1.1 ± 0.2 |
| Lg. Intestine | 2.2 ± 0.5 | 1.7 ± 0.2 | 0.8 ± 0.1 |
| Kidneys | 8.7 ± 2.4 | 6.5 ± 1.2 | 4.9 ± 0.5 |
| Muscle | 0.8 ± 0.3 | 1.5 ± 0.6 | 1.1 ± 0.2 |
| Bone | 3.8 ± 0.6 | 3.0 ± 0.9 | 2.3 ± 0.6 |
| Tail | 5.5 ± 3.6 | 3.2 ± 0.8 | 2.8 ± 0.4 |
| Testis | 3.7 ± 0.4 | 3.6 ± 0.5 | 3.1 ± 0.5 |