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. 2017 Aug 2;8(39):66154–66168. doi: 10.18632/oncotarget.19825

Figure 4. EDG2 played a vital role in LPA-induced EMT phenotype of SK-Hep1 cells.

Figure 4

(A) LPA treatment (5nM) resulted in increased migration ability of SK-Hep1 cells, while knockdown of EDG2 in SK-Hep1 cells abolished the impact of LPA on migration capacity of SK-Hep1. (B) Similiarly, invasion ability of SK-Hep1 cells was enhanced magnificently by LPA treatment, which was abated by knockdown of EDG2. (C) LPA decreased E-cadherin expression and increased the expression of N-cadherin, Fibronectin and Vimentin, while knockdown of EDG2 inhibited the influence of LPA on the expression of E-cadherin, N-cadherin, Fibronectin and Vimentin.