Table 2. Univariate and multivariate analyses of prognostic factors in HCC patients after liver resection.

Clinicopathological features	Univariate analysis		Multivariate analysis
	RR (95% CI)	P value	RR (95% CI)	P value
Age, year (<50 versus ≥50)	0.985 (0.523 - 1.698)	0.215	0.879 (0.497-1.538)	0.344
Gender (female versus male)	0.214 (0.085 – 1.052)	0.169	0.234 (0.099 – 1.106)	0.205
HBV infection	1.624 (0.897 – 1.689)	0.087	1.529 (0.745 – 1.429)	0.092
Serum AFP level (ng/mL) (≥ 400 versus < 400)	1.981 (0.987 - 2.681)	0.062	1.748 (0.878 – 1.540)	0.056
Tumor diameter (cm) (≥ 5 versus < 5)	2.158 (0.912 - 2.801)	0.051	1.908 (0.854 – 2.607)	0.077
Liver cirrhosis	1.533 (0.817 – 2.192)	0.084	1.301 (0.568-1.872)	0.095
Edmondson-Steiner classification (III + IV versus I + II)	1.687 (0.859 – 2.325)	0.107	2.157 (1.155 – 3.255)	0.115
Advanced TNM staging	1.632 (1.026 – 3.015)	0.042	1.354 (0.898 – 2.411)	0.081
Portal vein invasion	2.321 (1.523 – 3.544)	0.004	2.011 (1.341 – 3.017)	0.017
Intra-hepatic metastases	3.215 (2.218 – 4.028)	0.001	3.008 (2.012 – 3.752)	0.005
Higher EDG2 in tumor tissue	2.195 (1.485 – 3.658)	0.001	1.658 (1.035 – 2.958)	0.001