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. 2017 Aug 7;8(39):66305–66315. doi: 10.18632/oncotarget.19985

Table 2. Concordance between ACRG subtype classification by Affymetrix gene expression and targeted gene expression by NanoString.

Sample # Mesenchymal ACRG subtype EBV-ISH MSI MLH1 by IHC Lauren classification Pathology Stage
ACRG#1 non-mesenchymal MSI -0.17 negative MSS partial loss intestinal moderately differentiated adenocarcinoma IB
ACRG#2 mesenchymal MSS/EMT 0.32 negative MSS preserved diffuse signet ring cell carcinoma III
ACRG#3 mesenchymal MSS/EMT 0.37 positive MSS preserved diffuse poorly differentiated adenocarcinoma III
ACRG#4 mesenchymal MSS/EMT 0.53 negative MSS preserved mixed mucinous adenocarcinoma II
ACRG#5 mesenchymal MSS/EMT 0.19 negative MSS preserved diffuse poorly differentiated adenocarcinoma III
ACRG#6 non-mesenchymal MSI 0.24 negative MSS loss diffuse signet ring cell carcinoma III
ACRG#7 mesenchymal MSS/EMT 0.3 negative MSS preserved diffuse poorly differentiated adenocarcinoma IV
ACRG#8 mesenchymal MSS/EMT 0.12 negative MSS preserved diffuse poorly differentiated adenocarcinoma IV
ACRG#9 mesenchymal MSS/EMT 0.2 negative MSS preserved intestinal moderately differentiated adenocarcinoma III
ACRG#10 non-mesenchymal MSS/p53 active 0.03 negative MSS preserved intestinal moderately differentiated adenocarcinoma IB
ACRG#11 non-mesenchymal MSI -0.7 negative MSI-high loss diffuse moderately differentiated adenocarcinoma IB
ACRG#12 non-mesenchymal MSS/p53 active -0.3 negative MSS preserved intestinal moderately differentiated adenocarcinoma IB
ACRG#13 non-mesenchymal MSS/p53 inactive -0.44 negative MSS preserved diffuse poorly differentiated adenocarcinoma III
ACRG#14 non-mesenchymal MSI -0.27 negative MSI-high loss diffuse moderately differentiated adenocarcinoma II
ACRG#15 non-mesenchymal MSS/p53 active -0.28 negative MSS preserved diffuse poorly differentiated adenocarcinoma III
ACRG#16 non-mesenchymal MSS/p53 active -0.15 negative MSS preserved diffuse poorly differentiated adenocarcinoma III
ACRG#17 non-mesenchymal MSS/p53 inactive -0.15 ND ND preserved intestinal poorly differentiated adenocarcinoma IV
ACRG#18 non-mesenchymal MSI -0.52 negative MSS loss intestinal moderately differentiated adenocarcinoma IB
ACRG#19 non-mesenchymal MSS/p53 inactive -0.08 negative MSS preserved intestinal moderately differentiated adenocarcinoma III
ACRG#20 non-mesenchymal MSS/p53 inactive -0.49 negative MSS preserved intestinal moderately differentiated adenocarcinoma III
ACRG#21 non-mesenchymal MSI -0.72 negative MSS loss mixed moderately differentiated adenocarcinoma III
ACRG#22 non-mesenchymal MSS/p53 active 0.01 negative MSS preserved intestinal well differentiated adenocarcinoma II
ACRG#23 non-mesenchymal MSS/p53 inactive -0.24 positive MSS preserved diffuse poorly differentiated adenocarcinoma IV
ACRG#24 non-mesenchymal MSS/p53 inactive 0.01 negative MSS preserved diffuse poorly differentiated adenocarcinoma III
ACRG#25 non-mesenchymal MSI 0.02 negative MSS preserved diffuse poorly differentiated adenocarcinoma IV
ACRG#26 mesenchymal MSS/EMT 0.26 negative MSS preserved diffuse poorly differentiated adenocarcinoma III
ACRG#27 non-mesenchymal MSS/p53 inactive -0.58 negative MSI-high preserved diffuse poorly differentiated adenocarcinoma II
ACRG#28 non-mesenchymal MSS/p53 active 0.06 negative MSS preserved diffuse poorly differentiated adenocarcinoma IV
ACRG#29 non-mesenchymal MSS/p53 inactive -0.57 negative MSS preserved intestinal moderately differentiated adenocarcinoma III
ACRG#30 non-mesenchymal MSI 0.49 negative MSS preserved mixed moderately differentiated adenocarcinoma III
ACRG#31 non-mesenchymal MSI -0.58 ND MSI-high preserved intestinal poorly differentiated adenocarcinoma IB
ACRG#32 non-mesenchymal MSI -0.55 negative MSS preserved intestinal well differentiated adenocarcinoma IB
ACRG#33 non-mesenchymal MSS/p53 active -0.09 negative MSS preserved intestinal moderately differentiated adenocarcinoma III
ACRG#34 non-mesenchymal MSS/p53 active -0.2 negative MSS preserved diffuse poorly differentiated adenocarcinoma III
ACRG#35 non-mesenchymal MSS/p53 active -0.07 negative MSS preserved intestinal poorly differentiated adenocarcinoma IV
ACRG#36 non-mesenchymal MSS/p53 inactive -0.01 negative MSS preserved diffuse signet ring cell carcinoma IV
ACRG#37 non-mesenchymal MSS/p53 active -0.92 negative MSI-high preserved intestinal moderately differentiated adenocarcinoma IV
ACRG#38 non-mesenchymal MSI -0.29 negative MSS loss diffuse poorly differentiated adenocarcinoma III
ACRG#39 mesenchymal MSS/EMT -0.01 negative MSS preserved diffuse signet ring cell carcinoma III
ACRG#40 non-mesenchymal MSI -0.6 negative MSI-high loss intestinal moderately differentiated adenocarcinoma IB
ACRG#41 non-mesenchymal MSS/p53 active -0.46 negative MSS preserved intestinal poorly differentiated adenocarcinoma III
ACRG#42 non-mesenchymal MSS/EMT 0.12 negative loss diffuse signet ring cell carcinoma IV
ACRG#43 non-mesenchymal MSS/p53 active -0.22 negative MSS preserved intestinal moderately differentiated adenocarcinoma IV
ACRG#44 non-mesenchymal MSI -0.28 negative MSS loss intestinal moderately differentiated adenocarcinoma IV
ACRG#45 non-mesenchymal MSS/p53 active 0.12 positive MSS preserved intestinal poorly differentiated adenocarcinoma IV
ACRG#46 mesenchymal MSS/EMT 0.32 negative MSS preserved diffuse poorly differentiated adenocarcinoma IV
ACRG#47 non-mesenchymal MSS/p53 inactive -0.58 negative MSS preserved intestinal moderately differentiated adenocarcinoma II
ACRG#48 mesenchymal MSS/EMT 0.34 negative MSS preserved diffuse signet ring cell carcinoma III
ACRG#49 non-mesenchymal MSS/EMT -0.44 negative preserved diffuse signet ring cell carcinoma IV
ACRG#50 non-mesenchymal MSS/p53 active -0.22 positive preserved diffuse poorly differentiated adenocarcinoma IV
ACRG#51 non-mesenchymal MSI -0.22 negative NR24 only MSI preserved diffuse poorly differentiated adenocarcinoma IV
ACRG#52 non-mesenchymal MSI -0.43 negative NR24 only MSI preserved intestinal moderately differentiated adenocarcinoma III
ACRG#53 non-mesenchymal MSS/p53 active 0.22 negative preserved diffuse mucinous adenocarcinoma III
ACRG#55 non-mesenchymal MSS/p53 active -0.34 negative preserved diffuse others II
ACRG#56 non-mesenchymal MSI -0.15 negative preserved diffuse mucinous adenocarcinoma III
ACRG#57 non-mesenchymal MSS/p53 active 0.09 positive preserved diffuse poorly differentiated adenocarcinoma III
ACRG#58 non-mesenchymal MSI -0.67 negative loss intestinal moderately differentiated adenocarcinoma IV
ACRG#59 non-mesenchymal MSI -0.83 negative loss intestinal poorly differentiated adenocarcinoma III
ACRG#60 non-mesenchymal MSS/p53 active 0.27 negative preserved intestinal poorly differentiated adenocarcinoma III
ACRG#61 non-mesenchymal MSI -0.27 294 MSI-high loss 00283129 67
ACRG#62 non-mesenchymal MSS/p53 active 0.22 ND preserved diffuse signet ring cell carcinoma III
ACRG#63 non-mesenchymal MSS/p53 active 0.01 negative preserved intestinal poorly differentiated adenocarcinoma III
ACRG#64 non-mesenchymal MSS/p53 active 0.08 negative preserved diffuse poorly differentiated adenocarcinoma III
ACRG#65 mesenchymal MSS/EMT -0.07 negative preserved intestinal poorly differentiated adenocarcinoma III
ACRG#66 mesenchymal MSS/EMT 0.45 negative preserved diffuse signet ring cell carcinoma IV
ACRG#67 non-mesenchymal MSS/p53 inactive -0.2 negative preserved intestinal moderately differentiated adenocarcinoma III
ACRG#68 mesenchymal MSS/EMT 0.29 negative loss diffuse signet ring cell carcinoma IV
ACRG#69 non-mesenchymal MSI -0.7 negative loss mixed poorly differentiated adenocarcinoma III
ACRG#70 non-mesenchymal MSS/p53 active -0.44 negative preserved intestinal papillary adenocarcinoma II
ACRG#71 non-mesenchymal MSS/p53 active 0.24 positive preserved diffuse poorly differentiated adenocarcinoma III