Table 2. The Assessment of Bias of Included Trials.
| Source | Sequence generation |
Allocation concealment |
Blinding | Incomplete data addressed | Selective reporting | Other source of bias |
|---|---|---|---|---|---|---|
| INTERIST, 2008 and 2010 |
Low risk (Minimization) |
Low risk (Central allocation) |
Unclear risk | Low risk | Low risk | Low risk |
| TITAN, 2012 |
Low risk (Minimization) |
Low risk (Central allocation) |
Unclear risk | Low risk | Low risk | Halted prematurely because of slow recruitment |
| TAILOR, 2013 |
Low risk (Minimization) |
Low risk (Central allocation) |
Unclear risk | Low risk | Low risk | Low risk |
| CT/06.05, 2013 |
Low risk (Randomized numbers generated by computer) |
Low risk (Central allocation) |
Low risk (Central radiologic review) |
Low risk | Low risk | Low risk |
|
NCT01565538, 2014 |
Low risk (Randomized numbers generated by computer) |
Unclear risk | Unclear risk | Low risk | Low risk | 61% patients in pemetrexed arm crossed over to erlotinib, while 10% patients in erlotinib arm crossed over to pemetrexed. |
| PROSE, 2014 |
Low risk (Minimization) |
Low risk risk (Central allocation) |
Unclear risk | Low risk | Low risk | Low risk |
| DELTA, 2014 |
Low risk (Minimization) |
Low risk (Central allocation) |
Unclear risk | Low risk | Low risk | Low risk |
| CTONG 0806, 2014 |
Low risk (Minimization) |
Low risk risk (Central allocation) |
Low risk (Independent Review Committee ) |
Low risk | Low risk | More nonsmokers in CT arm (57.9% vs 40.7%, p = 0.03) |
| CheckMate 057, 2015 |
Low risk (Minimization) |
Low risk (Central allocation) |
Low risk (Central radiologic review) |
Low risk | Low risk | Low risk |
| KEYNOTE-010, 2015 |
Low risk (Randomized numbers generated by computer) |
Low risk (Central allocation) |
Low risk (Central radiologic review) |
Low risk | Low risk | Low risk |
| POPLAR, 2016 |
Low risk (Randomized numbers generated by bracket) |
High risk (undone) |
Low risk (Central radiologic review) |
Low risk | Low risk | Low risk |
| OAK, 2016 |
Low risk (Minimization) |
High risk (undone) |
Low risk ( Central radiologic review) |
Low risk | Low risk | Low risk |