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Histology-CT Fusion framework enables the mapping of invasive adenocarcinoma from histology onto CT via (1) the 3D reconstruction of the histology specimens, (2) a global search to identify the best fit of the reconstruction onto CT, (3) the refinement of the 3D histology reconstruction using CT as constraint, (4) the 3D-3D registration of CT to the histology reconstruction, and (5) the mapping of the histology reconstruction including the invasive component onto CT.
