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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Clin Trials. 2017 Jun 24;14(5):553–557. doi: 10.1177/1740774517715456

Table 1.

Simulated Phase I trial of complete information for a sample of 20 patients under an assumed set of true DLT probabilities.

Patient Tolerance True DLT probability at dose level i
j vj 0.05 0.07 0.20 0.35 0.55 0.70
1 0.606 0 0 0 0 0 1
2 0.703 0 0 0 0 0 0
3 0.891 0 0 0 0 0 0
4 0.441 0 0 0 0 1 1
5 0.115 0 0 1 1 1 1
6 0.247 0 0 0 1 1 1
7 0.686 0 0 0 0 0 1
8 0.968 0 0 0 0 0 0
9 0.967 0 0 0 0 0 0
10 0.464 0 0 0 0 1 1
11 0.958 0 0 0 0 0 0
12 0.441 0 0 0 0 1 1
13 0.008 1 1 1 1 1 1
14 0.843 0 0 0 0 0 0
15 0.221 0 0 0 1 1 1
16 0.500 0 0 0 0 1 1
17 0.294 0 0 0 1 1 1
18 0.143 0 0 1 1 1 1
19 0.671 0 0 0 0 0 1
20 0.506 0 0 0 0 1 1

Sample Proportions 0.05 0.05 0.15 0.30 0.55 0.70