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. Author manuscript; available in PMC: 2019 Feb 2.
Published in final edited form as: Prog Neuropsychopharmacol Biol Psychiatry. 2017 Apr 6;81:488–492. doi: 10.1016/j.pnpbp.2017.04.003

Figure 1. Direct expression of CRISPR/Cas9 in the brain.

Figure 1

Viral vectors (lentiviral, adenoviral, and AAV) or lipid-nanoparticles can be used to deliver CRISPR/Cas9 into a specific brain region in animals (e.g., mouse, non-human primates, and other species) via stereotaxic injection, resulting in gene editing in specific brain regions.