Fig. 2.

Longitudinal changes in the C-peptide response to the OGTT for 48 months in the patients with sitagliptin treatment and in the Tokyo study. Patients with 48 months of follow-up are shown. The data are expressed as the mean ± SEM. In both the ∑C-peptide values (a) and change ratios from baseline (b), a repeated-measures ANOVA revealed a significant interaction between time and treatment assignment (sitagliptin or insulin; p = 0.030 and p = 0.014, respectively) as well as between time and treatment assignment (sitagliptin or SU; p = 0.00004 and p = 0.007, respectively) in the longitudinal changes