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. 2017 Oct 6;7:12771. doi: 10.1038/s41598-017-12971-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(a) Cartoon showing GPCR positions with the most variants; size is proportional to variant count, numbers denote Pfam 7tm_1 alignment positions, with the Ballesteros/Weinstein scheme given in parantheses. (b) Fraction of GPCR genes containing variants at each domain position showing the proportion in OR (yellow) and non-OR (green) receptors highlighted. (c) Plots of the number of the standard deviations above (positive) or below (negative) the mean for each position within GPCR family A for eight species within Ensembl variations⁵⁶ having sufficient data for the analysis. The mean and standard-deviation are specific for each species and considering only variants within GPCR family A. The dip in the plot (between H5 and H6) is due to gaps within the alignment (i.e. fewer data points overall within this region).