Table 1.

PINTA detects increased V_CS flux in high-fat-fed rats treated with a liver-targeted mitochondrial uncoupler

Parameter	Control	CRMP
VPC/VCS	1.50 ± 27	0.48 ± 0.12**
VPC/VEGP	0.79 ± 0.05	0.60 ± 0.06*
EGP (μmol/(kg BW-min))	39 ± 1	33 ± 1**
VPC (μmol/(kg BW-min))	31 ± 3	20 ± 2**
VCS (μmol/(kg BW-min))	23 ± 4	49 ± 9*

V_PC/V_CS and V_PC/V_EGP ratios, as well as absolute rates of endogenous glucose production (EGP), V_PC, and V_CS flux were all measured using PINTA analysis of livers from rats infused with [3-¹³C]lactate. *P < 0.05, **P < 0.01 by the two-tailed unpaired Student’s t-test. Data are the mean ± S.E.M. of n = 5–6