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. 2017 Oct 6;8:797. doi: 10.1038/s41467-017-00842-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — miRNA profiling of H₂O₂-treated and APE1-knocked down HeLa cells. a Hierarchical-clustering analysis showing miRNAs differentially expressed in HeLa cell clones stably transfected with scrambled siRNA control (SCR), with an APE1 siRNA (siAPE) or SCR after stimulation with 1 mM H₂O₂ for 15 min. The heatmap diagram shows the centered miRNA expression values in logarithmic scale across the three groups of samples. b Empirical cumulative distribution function (ECDF) curves for expression changes (log fold change) of miRNAs-target genes (red line) vs. those of random mRNAs (blue line). Statistical significance of the difference between ECDFs is indicated (P-value from Kolmogorov–Smirnov (KS) test and Wilcoxon (WC))