Table 2.

The most enriched functional annotation disease clusters of APE1–RNA targets identified by Ingenuity Pathway Analysis

	Diseases	P-value	Score	# Molecules
Cancer	Epithelial cancer	1.11E−23	22.95	756
	Digestive system cancer	6.91E−20	19.16	701
	Colon cancer	3.46E−10	9.46	393
	Breast cancer	1.15E−05	4.94	158
	Ovarian cancer	2.78E−04	3.56	121
	Hematologic cancer	1.16E−03	2.94	209
Hematological	Anemia	8.72E−06	5.06	39
	High risk myelodysplastic syndrome	2.63E−04	3.58	3
	Lymphoproliferative disorder	4.37E−04	3.36	203
Neurological	Spinocerebellar ataxia	1.92E−04	3.72	13
	Disorder of basal ganglia	5.47E−04	3.26	64
	Early stage Alzheimer's disease	6.37E−04	3.20	3
	Neural tube defect	6.36E−05	4.20	19
	Movement disorders	1.55E−04	3.81	89
	Degeneration of nervous system	5.64E−04	3.25	29
Behaviour	Autistic-like traits	1.66E−03	2.78	2

P-value, enrichment score and number of molecules for each specific term are shown. APE1 apurinic/apyrimidinic endonuclease 1