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. 2017 Oct 6;8:793. doi: 10.1038/s41467-017-00925-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 9 — Scheme summarizing the main protumoral effects known for galectin-3 in the tumor microenvironment. Galectin-3 has been described to immobilize glycosylated proteins on the surface of T cells^{28, 30, 31, 32, 33}, IFNγ receptor on human fibroblasts and B cells⁵³, and VEGF receptor in human endothelial cells²⁷. In addition, galectin-3 favors collagen deposition by macrophages⁴⁸ and tumor cell migration⁵⁴. This figure does not intend to make an exhaustive review about all the effects published for galectin-3 but to highlight the ones that, in our opinion, can be working simultaneously in the tumor microenvironment