Table 1.
Tumor code | Tumor type | Untreated (*) | LacNAc | IFNγ | IFNγ + galectins antagonists | |||
---|---|---|---|---|---|---|---|---|
LacNAc | GM-CT-01 | αGal3 mIgG1 | αGal3 ratIgG | |||||
13-121 | Neuroendocrina | 1 (3) | 51 | 317 | 281 | N/A | N/A | N/A |
14-031 | Adenocarcinoma | 1 (12) | 1 | 5 | 2 | 2 | N/A | N/A |
13-212 | Adenocarcinoma | 1 (33) | 15 | 7 | 82 | N/A | N/A | N/A |
14-286 | Renal carcinoma | 1 (67) | N/A | 36 | 91 | 242 | N/A | |
14-581 | Pancreatic carcinoma | 1 (77) | 29 | 112 | 392 | 251 | 31 | 8 |
13-248 | Adenocarcinoma | 1 (78) | 2 | 1 | 3 | N/A | N/A | N/A |
13-480 | Adenocarcinoma | 1 (89) | 0 | 2 | 73 | 12 | N/A | N/A |
15-426 | Uterine carcinoma | 1 (139) | 2 | 2 | 5 | 10 | 1 | 1 |
12-477 | Adenocarcinoma | 1 (168) | 1 | 1 | 2 | N/A | N/A | N/A |
13-298 | Adenoma | 1 (193) | 2 | 2 | 5 | N/A | N/A | N/A |
13-568 | Hepatoadenoma | 1 (268) | 1 | 5 | 11 | 9 | N/A | N/A |
LB-3422 | Melanoma | 1 (379) | 0 | 1 | 16 | 2 | N/A | N/A |
14-063 | Adenocarcinoma | 1 (399) | 5 | 7 | 14 | 14 | N/A | N/A |
14-583 | Adenocarcinoma | 1 (406) | N/A | 2 | 7 | 2 | 4 | 8 |
15-427 | Adenocarcinoma | 1 (489) | 1 | 3 | 3 | 2 | 3 | 2 |
15-228 | Sarcoma | 1 (972) | 2 | 98 | 193 | 195 | 116 | 138 |
14-187 | Rectal adenocarcinoma | 1 (1065) | 1 | 1 | 5 | 3 | N/A | N/A |
13-420 | Lymphoma B diffuse | 1 (1278) | 2 | 2 | 2 | N/A | N/A | N/A |
14-526 | Renal carcinoma | 1 (1287) | 2 | 3 | 3 | 3 | 1 | 2 |
13-454 | Adenocarcinoma | 1 (1287) | 1 | 2 | 1 | N/A | N/A | N/A |
12-529 | Hepatoblastoma | 1 (1628) | 4 | 3 | 8 | N/A | N/A | N/A |
14-239 | Renal carcinoma | 1 (3321) | 1 | 2 | 2 | 1 | 1 | N/A |
12-549 | Leiomyoma | 1 (8056) | 14 | 5 | 33 | 40 | N/A | N/A |
Fold induction CXCL9 values using HPRT-1 as a reference gene and with respect to the untreated condition (2−ΔΔCt). For the untreated condition, CXCL9 mRNA levels normalized to HPRT-1 (103 × 2−ΔCt) are indicated in brackets. Human biopsies were treated for 6 h with IFNγ (50 ng ml−1), LacNAc (10 mM), GM-CT-01 (100 μg ml−1), and/or anti-galectin-3 antibodies (10 μg ml−1)
N/A no available data