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. 2017 Oct 6;7:12749. doi: 10.1038/s41598-017-13096-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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CypD ablation reduces I/R injury in hearts perfused with glucose, pyruvate, lactate and glutamine. (a) Lactate dehydrogenase (LDH) release during reperfusion as a percentage of total LDH in the heart. (b) Rate pressure product (RPP) at the end of reperfusion as percentage of baseline values. (c) End-diastolic pressure (EDP) at the end of reperfusion. (d) Developed left ventricular pressure (DLVP) at the end of reperfusion. n = 6–7 per group. Data are shown as mean + SEM. Mann-Whitney U tests were performed to test for significance between 1) control treated WT and CypD^−/− animals 2) control and IPC treated animals in WT and 3) CypD^−/− animals. *p < 0.05.