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. 2017 Oct 6;7:12749. doi: 10.1038/s41598-017-13096-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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CypD and IPC have no effect on end-ischemic mtHKII in hearts perfused with glucose, pyruvate, lactate and glutamine. (a) End-ischemic mitochondrial HK activity as ratio to CS activity. (b) Cytosolic HK activity normalized to protein content. (c) Representative Western blot images of mitochondrial HKII/VDAC and (d) cytosolic HKII/tubulin. The amount of end-ischemic mitochondrial (e) and cytosolic (f) HKII as ratio of VDAC and tubulin respectively, normalized to WT control. (g) Representative Western blot image and quantification (h) of whole homogenate pAkt/Akt, normalized to WT control. n = 6 per group. Data are shown as mean + SEM. Mann-Whitney U tests were performed to test for significance between 1) control treated WT and CypD^−/− animals 2) control and IPC treated animals in WT and 3) CypD^−/− animals. *p < 0.05.