Figure 5A, 5B.

Immunohistochemical (IHC) analysis of CCL5 (A)/CCR5 (B) protein expression in bone metastatic tissues following treatment with saline, WSZG (ig 3.25, 6.5, and 13.0 g·kg⁻¹·d⁻¹) or ZA (ip 100 μg/kg). Representative images of IHC staining are shown (original magnification ×200), white arrowheads note the immunoreactive cells in different groups and scale bar is 100 μm. IHC index are calculated by measuring three randomly selected microscopic fields for each slide (n=5, mean±SEM). ^*P<0.05, ^**P<0.01 vs normal group; ^#P<0.05, ^##P<0.01 vs model A group; ^$P<0.05, ^$$P<0.01 vs model B group. WSZG: Wenshen Zhuanggu formula; ZA: zoledronic acid.