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. Author manuscript; available in PMC: 2018 Oct 6.
Published in final edited form as: Org Lett. 2017 Sep 12;19(19):5010–5013. doi: 10.1021/acs.orglett.7b01611

Figure 4.

Figure 4

Proposed biosynthesis for Le-pyrrolopyrazine A–C (13) in L. enzymogenes through a portable mechanism of NRPS modules/domains, the expression of which was activated by swapping the native promoter with a strong constitutive promoter of the highly expressed HSAF biosynthetic pathway. 12