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. Author manuscript; available in PMC: 2018 Nov 30.
Published in final edited form as: J Pharm Biomed Anal. 2017 Aug 31;146:244–250. doi: 10.1016/j.jpba.2017.08.037

Table 1.

Stability of VX-970 under varying conditions.

Storage condition Concentration
(ng/mL)
Stability
(%)
CV
(%)
Replicates
VX-970

Stock solution 6 h
Ambient temp 100,000 96.7 10.6 3
Stock solution 8 months
 −80 °C 100,000 95.7 4.0 3
Plasma 4 h
Ambient temp. QCL 5    96.2 6.2 3
QCM 150    96.0 4.3 3
QCH 4000    100.2 0.5 3
Plasma 3 freeze-thaw cycles
 −80 °C QCL 5    98.1 3.9 4
QCM 150    99.6 5.0 4
QCH 4000    98.1 3.4 4
Plasma 8 months
 −80 °C QCL 5    92.2 4.6 4
QCM 150    100.1 3.8 4
QCH 4000    96.2 4.0 4