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. Author manuscript; available in PMC: 2018 Sep 5.
Published in final edited form as: Semin Immunol. 2017 Sep 5;31:64–75. doi: 10.1016/j.smim.2017.07.011

Figure 2. Design and function of tumor antigen-specific bi- and tri-specific killer engagers (BiKEs and TriKEs).

Figure 2

A) Schema of the basic design and structure of a BiKE consisting of an anti-CD16 scFV linked to an scFv specific to a tumor-expressed antigen or B) a TriKE of the same design including the cytokine, IL-15, included as a linker between the two scFv components. C) Proposed function of tumor antigen-specific BiKE and TriKE.