Table 2.
Regional c-FOS Immunoreactivity in Non-FST and in FST Exposed WKY Rats Treated with Vehicle or ZL006
| Brain region |
Non-FST
Vehicle |
Non-FST
ZL006 |
FST Vehicle | FST ZL006 |
|---|---|---|---|---|
| Cortical | ||||
| PLx | 128.8 ± 3.67 | 123.6 ± 8.02 | 166.0 ± 13.05 | 281.8 ± 28.65** |
| ILx | 124.4 ± 5.31 | 125.7 ± 15.15 | 104.2 ± 4.78 | 172.3 ± 22.69** |
| Cgx | 69.60 ± 8.27 | 68.70 ± 8.36 | 197.8 ± 12.75++ | 119.0 ± 22.11** |
| LS | 93.25 ± 7.73 | 99.00 ± 11.03 | 140.4 ± 6.47++ | 195.5 ± 11.64** |
| Subcortical | ||||
| NAc (shell) | 47.08 ± 4.30 | 48.75 ± 4.22 | 121.5 ± 24.67++ | 124.8 ± 14.32 |
| NAc (core) | 54.67 ± 6.20 | 52.33 ± 4.09 | 90.67 ± 11.52+ | 133.9 ± 16.04** |
| PVN | 50.58 ± 4.46 | 52.17 ± 1.08 | 132.3 ± 2.88++ | 166.5 ± 6.44** |
| PVT | 42.50 ± 2.09 | 41.17 ± 3.20 | 82.50 ± 7.57++ | 73.83 ± 11.58 |
| CeA | 34.25 ± 3.82 | 33.92 ± 2.91 | 28.00 ± 2.73 | 34.17 ± 5.85 |
| Bla | 38.90 ± 4.25 | 40.25 ± 4.06 | 35.58 ± 2.05 | 38.83 ± 4.74 |
| MeA | 35.00 ± 1.29 | 37.75 ± 6.93 | 42.92 ± 3.62 | 40.83 ± 4.54 |
| Hippocampus | ||||
| dDG | 16.40 ± 0.53 | 15.13 ± 1.23 | 33.42 ± 2.65++ | 19.33 ± 1.67** |
| vCA1 | 27.08 ± 2.69 | 32.17 ± 5.03 | 70.17 ± 5.12++ | 36.42 ± 4.40** |
| Brainstem | ||||
| DRN | 67.00 ± 12.19 | 69.83 ± 11.74 | 90.50 ± 13.77 | 118.0 ± 9.71 |
| dlPAG | 48.92 ± 3.29 | 57.00 ± 2.12 | 103.8 ± 4.98++ | 160.8 ± 11.46** |
+P<.05 relative to corresponding vehicle group. ++P<.01 relative to corresponding vehicle group. **P<.01 relative to corresponding FST vehicle-treated group.