Table 1.
Influence of CUS and Drug Treatment on Water Consumption and Locomotor Activity in Wild-Type Mice
| Treatment Group | Water ConsumptionMean (g) ± SEM | Locomotor ActivityMean (m) ± SEM |
|---|---|---|
| Control (vehicle) | 1.87 ± 0.11 | 35.1 ± 1.6 |
| CUS + vehicle | 1.95 ± 0.09 | 35.8 ± 4.7 |
| CUS + CAR (0.03 mg/kg; b.i.d.) | 2.01 ± 0.09 | 30.1 ± 1.6 |
| CUS + CAR (0.1 mg/kg; b.i.d.) | 1.96 ± 0.10 | 30.4 ± 2.0 |
| CUS + CAR (0.2 mg/kg; b.i.d.) | 2.03 ± 0.10 | 29.1 ± 1.4 |
| CUS + IMI (20 mg/kg) | 2.03 ± 0.10 | 30.6 ± 3.4 |
Abbreviations: b.i.d., twice a day; CAR, cariprazine; CUS, chronic unpredictable stress; IMI, imipramine.
There were no overall significant effects of CUS or drug treatment using ANOVA.