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. 2017 Sep 20;2017:3269379. doi: 10.1155/2017/3269379

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Copyright © 2017 Eman A. Toraih et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Structural analysis of MIR-34A gene locus and transcripts. (a) Homo sapiens hairpin secondary structure of pre-miR-34a stem-loop. Mature miR-34a-5p highlighted in red [data source: miRTarBase v20]. (b) Enrichment pathway analysis for miR-34a. Heat map showing targeted pathways, diseases, and cancers for both hsa-miR-34a-5p and hsa-miR-34a-3p with p values < 0.05 and microT-CDS threshold 0.4. A total of 33 pathways have target genes (in CDS or 3′ UTR regions) for miR-34a. The enrichment results of validated target genes showed that most pathways were related to cancer and cancer-related pathways. KEGG pathway annotations related specifically to current RCC work had been labeled (red). Degree of color is based on the significant p values of the predicted algorithm by DIANA tools; the red has the top significance estimated by false discovery rate (data source: DIANA-miRPath v2.0 web server).