Table 1.
Characteristics of the study population.
| Parameters | ACTH-dependent CS (n = 16) | ACTH-independent CS (n = 10) | Control (n = 16) | p value |
|---|---|---|---|---|
| Age (years) | 44.1 ± 13.5 | 43.8 ± 9.8 | 43.9 ± 10.3 | 0.869 |
| Leukocytes (mm3) | 9460.0 ± 2429.2 | 7508.7 ± 1329.8 | 5842.0 ± 1279.2 | <0.001 ∗∗ |
| Neutrophils (mm3) | 6562.5 ± 2093.7 | 5062.5 ± 1329.8 | 3270.0 ± 960.4 | <0.001 ∗∗ |
| Lymphocytes (mm3) | 2031.2 ± 710.6 | 1725.0 ± 549.6 | 1870.0 ± 533.4 | 0.522 |
| Monocytes (mm3) | 562.5 ± 224.7 | 425.0 ± 128.1 | 330.0 ± 94.8 | 0.008 ∗ |
| T2D (%) | 5 (31) | 3 (30) | 0 (0) | 0.341 |
| HTA (%) | 8 (50) | 5 (50) | 0 (0) | 0.145 |
| DLP (%) | 3 (19) | 3(30) | 0 (0) | 0.271 |
| Obesity (%) | 8 (50) | 5 (50) | 1 (6) | 0.215 |
| BMI (kg/m2) | 29.4 ± 5.1 | 29.2 ± 13.1 | 24.2 ± 4.2 | 0.339 |
| Waist C (cm) | 94.7 ± 14.1 | 94.2 ± 18.3 | 77.5 ± 11.7 | 0.037 ∗ |
| WHR | 0.90 ± 0.1 | 0.89 ± 0.1 | 0.71 ± 0.1 | 0.024 ∗ |
| TC (mmol/l) | 5.6 ± 0.8 | 5.5 ± 0.5 | 4.5 ± 0.5 | 0.020 ∗ |
| TG (mmol/l) | 1.4 ± 0.6 | 1.4 ± 0.5 | 0.9 ± 0.6 | 0.238 |
| LDL-c (mmol/l) | 3.4 ± 0.5 | 3.4 ± 0.6 | 2.5 ± 0.6 | 0.016 |
| HDL-c (mmol/l) | 1.5 ± 0.4 | 1.5 ± 0.3 | 1.7 ± 0.6 | 0.355 |
| Hs-CRP (mg/dl) | 0.36 ± 0.36 | 0.30 ± 0.31 | 0.02 ± 0.01 | 0.038 ∗ |
| Glucose (mmol/l) | 6.5 ± 2.7 | 6.1 ± 0.7 | 5.2 ± 0.6 | 0.268 |
| HOMA-IR | 3.80 ± 2.51 | 3.69 ± 2.23 | 2.89 ± 2.91 | 0.482 |
| HbA1c (DCCT) | 6.8 ± 1.9 | 6.6 ± 0.5 | 5.4 ± 0.2 | 0.076 |
| UFC-24hs (mcg/24hs) | 269.2 ± 114.8 | 257.7 ± 118.1 | 44.8 ± 12.6 | 0.029 ∗ |
| ACTH (pg/ml) | 68.4 ± 73.5 | 5.6 ± 1.4 | 33.5 ± 7.3 | 0.023 ∗ |
Data are expressed as mean ± standard deviation. Qualitative variables are expressed as percentages. BMI: body mass index; HOMA-IR: homeostasis model assessment for insulin resistance; T2D: type 2 diabetes; HbA1c (DCCT): haemoglobin A1c (diabetes control and complication trial units); Hs-CRP: high-sensitivity C-reactive protein; LDL-c: low-density lipoprotein cholesterol; HDL-c: high-density lipoprotein cholesterol; WHR: waist/hip ratio. ∗p < 0.05. ∗∗p < 0.001.