Table 3.
Cell surface marker phenotyping of immune cells.
| Parameters | ACTH-dependent CS (n = 16) | ACTH-independent CS (n = 10) | Controls (n = 16) | p value |
|---|---|---|---|---|
| Monocytes | ||||
| CD14++CD16− classical (% MN) | 32.7 ± 29.2 | 36.4 ± 33.8 | 42.2 ± 32.5 | 0.805 |
| CD14++CD16−11b+ (%) | 63.4 ± 37.5 | 86.6 ± 15.5 | 80.8 ± 19.6 | 0.195 |
| CD14++CD16+ intermediate (% MN) | 37.6 ± 25.1 | 34.2 ± 27.0 | 28.7 ± 26.2 | 0.748 |
| CD14++CD16+11b+ (%) | 47.7 ± 43.7 | 59.8 ± 49.1 | 48.1 ± 48.7 | 0.845 |
| CD14+CD16++ Nonclassical (% MN) |
4.9 ± 1.9 | 8.9 ± 3.5 | 5.8 ± 3.8 | 0.019 ∗ |
| CD14+CD16++11b+ (%) | 29.1 ± 38.7 | 52.9 ± 48.0 | 35.4 ± 41.1 | 0.608 |
| Neutrophils | ||||
| CD15+ (% N) | 65.5 ± 27.5 | 66.3 ± 21.2 | 47.1 ± 13.9 | 0.205 |
| CD15+CD16+ (%) | 64.4 ± 28.0 | 70.2 ± 21.6 | 44.3 ± 12.7 | 0.103 |
| CD15+CD16+ 11b (%) | 74.2 ± 30.7 | 90.5 ± 15.3 | 69.2 ± 29.1 | 0.313 |
| CD16+11b (% N) | 85.9 ± 28.8 | 96.4 ± 1.5 | 94.2 ± 4.2 | 0.495 |
| Lymphocytes | ||||
| CD3+CD8+ (% L) | 27.9 ± 14.1 | 33.2 ± 8.0 | 26.8 ± 8.1 | 0.496 |
| CD3+CD4+ (%L) | 43.6 ± 21.6 | 53.4 ± 12.6 | 54.2 ± 6.6 | 0.300 |
| CD3+CD4+CD25+ (%) | 18.7 ± 16.7 | 23.7 ± 22.7 | 22.7 ± 11.1 | 0.813 |
| NK (% L) | 30.8 ± 31.8 | 40.3 ± 34.4 | 18.4 ± 18.5 | 0.359 |
| NK CD11b+ (%) | 26.4 ± 31.2 | 47.6 ± 40.9 | 37.5 ± 44.4 | 0.541 |
Data are expressed as % ± standard deviation. MN: monocytes; N: neutrophils; L: lymphocytes. ∗p < 0.05.