. Author manuscript; available in PMC: 2018 Aug 23.

Published in final edited form as: J Am Chem Soc. 2017 Aug 14;139(33):11595–11600. doi: 10.1021/jacs.7b06794

Table 4.

Palladium-catalyzed atom-transfer radical cyclizations of unactivated alkyl bromides.

entry	substrate	product	yield (%)^a
1			45 (57:43 dr)
2			30
3			26
4			60 (50:50 dr)
5			84^b (60:40 dr)

Reactions performed with [substrate]₀ = 0.25 M in PhCF₃ at 80 °C with 5 mol % [Pd(allyl)Cl]₂, 20 mol % dtbpf, and 0.5 equiv Et₃N as base.

Isolated yield.

Yield determined by ¹H NMR spectroscopy using 1,3,5-trimethoxybenzene as internal standard.