| Bantam |
Caste determination; target of hippo and EGFR/MAPK signaling pathways; critical in embryonic development and the control of cell proliferation and survival; up-regulated in 4-day-old queen larvae compared with 4-day-old worker larvae; related to insulin and Wnt pathway. |
Ashby et al. (2016), Shi et al. (2015)
|
Down-regulated |
Up-regulated but not significantly |
Down-regulated but not significantly |
| Let-7 |
Caste determination; major target of steroid pathways; miRNA markers associated with the behavioural shift of worker bees from nurses to forages; immune-related; Vg positive correlation; participated in regulation of behavioral maturation in honey bees; associated with reproductive statuses; up-regulated in the inactive ovaries; up-regulated in 4-day-old queen larvae; related to Wnt pathway; down-regulated in Ec knock down bees |
Ashby et al. (2016), Macedo et al. (2016), Mello et al. (2014), Nunes et al. (2013), Shi et al. (2015)
|
Down-regulated |
No change |
Up-regulated but not significantly |
| Ame-mir-1 |
Vg positive correlation; associated with reproductive statuses; up-regulated in the inactive ovaries; down-regulated in Ec knock down bees |
Macedo et al. (2016), Mello et al. (2014), Nunes et al. (2013)
|
Down-regulated |
No change |
Down-regulated but not significantly |
| Ame-mir-10 |
Up-regulated in 4-day-old queen larvae |
Shi et al. (2015) |
Up-regulated |
Down-regulated |
Up-regulated but not significantly |
| Ame-mir-100 |
20E and JH response miRNA; caste determination; associated with reproductive statuses; up-regulated in the inactive ovaries |
Ashby et al. (2016), Macedo et al. (2016)
|
Down-regulated |
Down-regulated but not significantly |
Up-regulated but not significantly |
| Ame-mir-12 |
Associated with reproductive statuses; up-regulated in 4-day-old queen larvae compared with 4-day-old worker larvae; related to insulin and MAPK pathway; down-regulated in Ec knock down bees |
Macedo et al. (2016), Mello et al. (2014), Shi et al. (2015)
|
Down-regulated but not significantly |
Up-regulated |
Down-regulated but not significantly |
| Ame-mir-125 |
20E and JH response miRNA; caste determination; up-regulated in the inactive ovaries; up-regulated in 4-day-old queen larvae compared with 4-day-old worker larvae; related to insulin, MAPK and mTOR pathway |
Ashby et al. (2016), Macedo et al. (2016), Shi et al. (2015)
|
Down-regulated |
Down-regulated but not significantly |
Up-regulated but not significantly |
| Ame-mir-133 |
Associated with the lipid loss in bees; participated in regulation of behavioral maturation in honey bees; up-regulated in 4-day-old queen larvae; related with MAPK pathway; down-regulated in Ec knock down bees |
Mello et al. (2014), Nunes et al. (2013), Shi et al. (2015)
|
Down-regulated |
No change |
Down-regulated but not significantly |
| Ame-mir-14 |
Caste determination; negatively related with Ec R expression and activity; up-regulated in 4-day-old queen larvae compared with 4-day-old worker larvae; related to insulin, MAPK, mTOR and Wnt pathway; down-regulated in Ec knock down bees; up-regulated in the activated ovaries |
Ashby et al. (2016), Macedo et al. (2016), Mello et al. (2014), Shi et al. (2015)
|
Down-regulated |
No change |
Up-regulated but not significantly |
| Ame-mir-184 |
Stable expression in active and inactive ovary; plays key roles in embryogenesis; the determination of the anteroposterior axis; embryo cellularization and stem cell determination; up-regulated in 4-day-old queen larvae compared with 4-day-old worker larvae; related to insulin pathway; down-regulated in Ec knock down bees; a miRNA in royal jelly and affect caste determination |
Guo et al. (2013), Macedo et al. (2016), Mello et al. (2014), Shi et al. (2015)
|
Down-regulated |
No change |
Down-regulated but not significantly |
| Ame-mir-190 |
Caste determination; immune-related |
Ashby et al. (2016) |
Down-regulated |
No change |
Down-regulated but not significantly |
| Ame-mir-252a |
Up-regulated in 4-day-old queen larvae; up-regulated in the activated ovaries |
Macedo et al. (2016), Shi et al. (2015)
|
Down-regulated |
Down-regulated but not significantly |
Up-regulated but not significantly |
| miR-263a |
Associated with reproductive statuses; up-regulated in the inactive ovaries; down-regulated in Ec knock down bees |
Macedo et al. (2016), Mello et al. (2014)
|
Up-regulated |
Down-regulated but not significantly |
Up-regulated but not significantly |
| Ame-mir-275 |
Vg positive correlation; up-regulated in 4-day-old queen larvae; related to insulin and MAPK pathway |
Nunes et al. (2013), Shi et al. (2015)
|
Down-regulated |
Up-regulated |
Up-regulated but not significantly |
| Ame-mir-276 |
Associated with reproductive statuses; up-regulated in the inactive ovaries; down-regulated in Ec knock down bee; up-regulated in 4-day-old queen larvae compared with 4-day-old worker larvae |
Macedo et al. (2016), Mello et al. (2014), Shi et al. (2015)
|
Down-regulated |
Up-regulated |
No change |
| Ame-mir-279 |
Caste determination; immune-related; down-regulated in Ec knock down bees |
Ashby et al. (2016) |
Up-regulated |
No change |
Down-regulated but not significantly |
| Ame-mir-2796 |
Participated in regulation of behavioral maturation in honey bees |
Nunes et al. (2013) |
Down-regulated |
Down-regulated but not significantly |
Down-regulated but not significantly |
| Ame-mir-279a-3p |
Up-regulated in the activated ovaries |
Macedo et al. (2016) |
Down-regulated |
Up-regulated but not significantly |
Down-regulated but not significantly |
| Ame-mir-279b-3p |
Up-regulated in the activated ovaries |
Macedo et al. (2016) |
Up-regulated |
No change |
Down-regulated but not significantly |
| Ame-mir-2944-3p |
Up-regulated in the activated ovaries |
Macedo et al. (2016) |
Up-regulated |
Down-regulated but not significantly |
Up-regulated but not significantly |
| Ame-mir-305 |
Down-regulated in Ec knock down bees |
Mello et al. (2014) |
Down-regulated but not significantly |
Up-regulated |
Up-regulated but not significantly |
| Ame-mir-306 |
Associated with reproductive statuses; up-regulated in the activated ovaries; targets ATPsyn-beta-PA; down-regulated in Ec knock down bees |
Macedo et al. (2016), Mello et al. (2014)
|
Up-regulated |
Down-regulated but not significantly |
Down-regulated but not significantly |
| Ame-mir-315 |
Caste determination; modulates tissue patterning and cell differentiation |
Ashby et al. (2016) |
Up-regulated |
Down-regulated but not significantly |
Down-regulated but not significantly |
| Ame-mir-316 |
Vg negative correlation; related to Wnt pathway; down-regulated in Ec knock down bees |
Mello et al. (2014), Nunes et al. (2013)
|
Down-regulated |
Up-regulated but not significantly |
No change |
| Ame-mir-317 |
Associated with reproductive statuses; up-regulated in the activated ovaries; related to insulin pathway; down-regulated in Ec knock down bees |
Macedo et al. (2016), Mello et al. (2014)
|
Down-regulated |
Up-regulated but not significantly |
No change |
| Ame-mir-31a |
Vg negative correlation; associated with reproductive statuses; up-regulated in the inactive ovaries |
Macedo et al. (2016), Nunes et al. (2013)
|
Down-regulated |
Up-regulated but not significantly |
Down-regulated but not significantly |
| Ame-mir-33 |
Caste determination; immune-related |
Ashby et al. (2016) |
Down-regulated |
Up-regulated but not significantly |
No change |
| Ame-mir-3718a |
Vg negative correlation |
Nunes et al. (2013) |
Down-regulated |
No change |
Up-regulated but not significantly |
| Ame-mir-375 |
Up-regulated in 4-day-old queen larvae; related to MAPK pathway |
Shi et al. (2015) |
Down-regulated |
No change |
Up-regulated but not significantly |
| Ame-mir-6001-3p |
Up-regulated in 4-day-old queen larvae |
Shi et al. (2015) |
Down-regulated |
Not detected |
Up-regulated but not significantly |
| Ame-mir-71 |
Participates in specific steps of the insulin/insulin-like signaling pathway |
Macedo et al. (2016) |
Down-regulated but not significantly |
Up-regulated |
Up-regulated but not significantly |
| Ame-mir-8 |
Caste determination; immune-related; 20E and JH response miRNA; related to Wnt pathway; up-regulated in the activated ovaries |
Ashby et al. (2016), Macedo et al. (2016), Shi et al. (2015)
|
Down-regulated |
Up-regulated |
No change |
| Ame-mir-92a |
Vg negative correlation; participated in regulation of behavioral maturation in honey bees; associated with reproductive statuses; down-regulated in Ec knock down bees |
Macedo et al. (2016), Mello et al. (2014), Nunes et al. (2013)
|
Up-regulated |
Down-regulated but not significantly |
No change |
| Ame-mir-92b |
Up-regulated in the activated ovaries; related to insulin, MAPK and mTOR pathway; down-regulated in Ec knock down bees |
Macedo et al. (2016), Mello et al. (2014), Shi et al. (2015)
|
Up-regulated |
Down-regulated |
Up-regulated but not significantly |
| Ame-mir-993 |
Related to insulin pathway |
Shi et al. (2015) |
Down-regulated |
Up-regulated but not significantly |
Down-regulated but not significantly |
| Ame-mir-996 |
Related to insulin pathway |
Shi et al. (2015) |
Down-regulated but not significantly |
Up-regulated |
Down-regulated but not significantly |
