Table 1.

The performance of several sequential SW-CRT designs (Designs 1–6), along with that of the corresponding classical SW-CRT design (Design 7), is summarised, for Scenarios 1 and 2.

Scenario 1
Design	$\mathcal{T}$	Stopping	${\gamma }_e$	${\gamma }_f$	$m$	$\mathbb{E}(M|0)$	$\mathbb{P}(\mathrm{Reject}{H}_0|0)$	$\mathbb{E}(M|\delta )$	$\mathbb{P}(\mathrm{Reject}{H}_0|\delta )$	$minM$	$maxM$
Design 1	{2,3,4,5}	E&F	0.5	0.5	104	1043.49	0.05	1113.17	0.90	832	2080
Design 2	{3,5}	F	NA	1	75	1031.73	0.05	1464.44	0.90	900	1500
Design 3	{3,4,5}	E	1	NA	97	1912.03	0.05	1288.63	0.93	1164	1940
Design 4	{2,3,4,5}	E&F	1.5	1	84	946.52	0.05	1040.49	0.90	672	1680
Design 5	{3,5}	F	NA	1.5	73	1032.61	0.05	1433.30	0.90	876	1460
Design 6	{3,4,5}	E	0.5	NA	104	2044.88	0.05	1353.52	0.95	1248	2080
Design 7	{5}	NA	NA	NA	70	1400.00	0.05	1400.00	0.90	1400	1400
Scenario 2
Design 1	{2,4,7,9}	E&F	0.5	0.5	11	878.21	0.05	1063.59	0.81	440	1980
Design 2	{5,9}	F	NA	1	9	856.89	0.05	1037.91	0.82	900	1620
Design 3	{3,6,9}	E	1	NA	8	1416.43	0.05	1031.39	0.81	480	1440
Design 4	{2,4,7,9}	E&F	1.5	1	9	1583.44	0.05	1084.97	0.82	360	1620
Design 5	{5,9}	F	NA	1.5	8	924.10	0.05	1365.12	0.82	800	1440
Design 6	{3,6,9}	E	0.5	NA	8	952.90	0.05	1382.72	0.83	480	1440
Design 7	{9}	NA	NA	NA	7	1260.00	0.05	1260.00	0.81	1260	1260

E&F: efficacy and futility; E: efficacy; F: futility; NA: not applicable.

All rounding is to two decimal places.