Fig. 1. Constitutive and genotoxin-induced expression of DNA Pol κ in DRG Neurons.
(a) Comparison of region specific PolK and PolB mRNA levels (log2) in the mouse brain (Allen Brain Atlas ISH data). (b) Real-time (RT) qPCR analyses of PolK mRNA levels relative to 18S or PolB in cortical and DRG neurons. (c) RT-qPCR analyses of genes encoding DNA repair proteins in DRG neurons exposed 24 h to 10 μM cisplatin, 0.2 μM doxorubicin or 30 μM cytarabine (ara-C). Spider graph shows mean mRNA levels of 15 DNA repair proteins. Data are pooled from 4 independent biological experiments. Fold-change is indicated on vertical axis.