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. 2017 Oct 4;8:757. doi: 10.3389/fphys.2017.00757

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Copyright © 2017 Colman, Perez Alday, Holden and Benson.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Action potential and ECG morphology and duration in PQT and MC-II-157c. (A) Action potentials for the three cell types (ENDO, left; M, middle; EPI, right) under baseline (upper) and MC-II-157c (lower) conditions in control (WT, purple) and PQTa-c conditions (blue, green, red) in the spatial cell model. (B) Action potential duration at −80 mV for the same conditions in (A). The colors in the key apply to both panels (A,B). (C) Computed ECGs for the three conditions (dotted red line) and with the application of MC-II-157c (black line), relative to the WT (purple line). MC-II-157c was modeled as I_Kr modification + 40% I_Na block. Any impact of I_Na block on the upstroke velocity is not clear at this scale.