Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Oct 4;8:757. doi: 10.3389/fphys.2017.00757

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2017 Colman, Perez Alday, Holden and Benson.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Development of triggered action potentials in single cell. (A) 100 Action Potential traces for control (WT, left) and PQTb (right) under baseline (upper) and MC-II-157c (lower) conditions, associated with spontaneous Ca²⁺ release events. A proportion of the DADs manifest as triggered action potentials in all conditions. (B) Probability of DADs triggering full action potentials for control (WT) and PQTa-c under baseline and MC-II-157c conditions. The degree of I_Na block associated with MC-II-157c is varied between 0% (I_Kr only), 40 and 80%. The upper panel corresponds to a median RyR waveform duration of 350 ms; the lower panel to 300 ms. (C) Illustration of the mechanism by which MC-II-157c inhibits triggered activity, showing that the larger I_Kr (lower panel and inset) acts to oppose depolarising currents during the DAD. Yellow highlighted region clearly illustrates the differences between the conditions.