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. 2017 Oct 4;8:757. doi: 10.3389/fphys.2017.00757

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Copyright © 2017 Colman, Perez Alday, Holden and Benson.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Development of premature excitation in 2D tissue sheets. Temporal snapshots of the membrane voltage in a 2D slice of tissue during spontaneous Ca²⁺ release events for PQTa (A) and PQTa + MC-II-157c (I_Kr modification + 40% I_Na block, (B). The color bar has been scaled to emphasize voltage differences in the DAD region and lighting has been added to further enhance local variation in voltage. Data corresponds to t_i width of 550 ms and duration median 150 ms.